Research
Ultimate Guide to Anti-Inflammatory Skincare for PCOS
Learn how to effectively manage PCOS-related skin issues with anti-inflammatory skincare, dietary changes, and lifestyle tips for healthier skin.
June 17, 2025
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Learn how to effectively manage PCOS-related skin issues with anti-inflammatory skincare, dietary changes, and lifestyle tips for healthier skin.
Managing PCOS-related skin issues starts with calming inflammation and controlling oil production. If you're struggling with acne, oily skin, or redness due to PCOS, here’s what you need to know:
The hormonal imbalances associated with PCOS can lead to skin inflammation. Elevated male hormones, insulin resistance, and chronic low-grade inflammation are key factors that make the skin more prone to oiliness, breakouts, and heightened sensitivity. Together, these processes create a perfect storm for skin issues by increasing oil production and making the skin more reactive.
Dr. Frank González highlights this connection, stating, "a dietary trigger like glucose can induce oxidative stress and stimulate an inflammatory response even without excess adiposity. Hyperandrogenism may initiate chronic low‐grade inflammation". This means the body often remains in a state of mild, ongoing inflammation, which not only affects the skin but also slows its ability to heal.
This inflammation isn’t just skin-deep - it’s systemic, impacting the entire body. Research has found that individuals with PCOS often have higher levels of inflammatory markers, such as C-Reactive Protein (CRP), and increased oxidative stress. These factors can show up on the skin as persistent acne, redness, and sensitivity.
Androgens, especially testosterone, play a major role in triggering the skin’s sebaceous glands to produce excessive amounts of oil, or sebum. This is why people with PCOS often experience oily, shiny skin. Hyperandrogenism - a condition affecting 60–80% of women with PCOS - is a major driver of this process. In one study of 86 women with PCOS, 65% had elevated testosterone levels, and 88% showed higher-than-normal androstenedione concentrations.
These androgens stimulate sebocytes and follicular keratinocytes, leading to increased cell growth and clogged pores, which are key contributors to acne. Insulin resistance, which affects 65–70% of women with PCOS, further worsens the issue by prompting the ovaries to release even more androgens. As a result, acne is a common concern, affecting 10–34% of individuals with PCOS. It often appears on the face, neck, chest, and upper back. The excess sebum can also lead to enlarged pores and blackheads.
Hormonal imbalances don’t just increase oil production - they also fuel chronic inflammation, which worsens skin problems. PCOS is recognized as a low-grade inflammatory condition, and this persistent inflammation makes the skin more sensitive and prone to breakouts. It also slows the skin’s ability to recover, prolonging the healing process.
Studies show that even individuals with PCOS who are not overweight have elevated levels of inflammatory markers like CRP. This ongoing inflammation can interfere with how the skin responds to treatments, making it essential to adopt a skincare routine that targets both excess oil and inflammation.
Understanding how these mechanisms interact is key to choosing effective solutions that address the root causes of PCOS-related skin issues. Anti-inflammatory skincare can play a critical role in improving both the appearance and health of the skin.
Managing PCOS-related skin issues starts with addressing inflammation at its root. The right ingredients can help calm irritation, unclog pores, and balance oil production, leading to healthier, more resilient skin.
Salicylic acid is a go-to for PCOS skin because it tackles two major concerns: inflammation and clogged pores. As a beta-hydroxy acid, it penetrates deep into the skin to break down excess oil and dead skin cells, all while gently exfoliating to curb overactive sebum production.
Azelaic acid is another standout for inflamed, sensitive skin. It not only reduces redness and fights acne-causing bacteria but also helps fade post-inflammatory hyperpigmentation - those stubborn dark spots left behind after breakouts. Its gentle nature makes it suitable for both morning and evening routines, and it pairs well with other anti-inflammatory ingredients.
For even better results, consider pairing these acids with ingredients that strengthen the skin's natural barrier.
Niacinamide (vitamin B3) is a multitasking powerhouse for PCOS skin care. It helps control oil production, calms inflammation, strengthens the skin barrier, and improves overall texture while reducing redness. Plus, it’s gentle enough to use alongside other active ingredients.
Green tea extract is packed with antioxidants that soothe inflammation and shield the skin from oxidative stress. Its polyphenols, particularly EGCG (epigallocatechin gallate), provide long-lasting calming effects, making it ideal for skin prone to chronic low-grade inflammation associated with PCOS. Look for moisturizers or serums enriched with green tea extract for added benefits.
Beyond these, there are other actives and oils worth incorporating into your routine.
Retinoids, derived from vitamin A, are highly effective for treating acne and reducing inflammation. They promote faster cell turnover, prevent clogged pores, and target persistent acne. Since PCOS-related acne often involves deeper, more stubborn lesions, retinoids can be a game-changer. If you have sensitive skin, start with a lower concentration and gradually increase to avoid irritation.
Natural oils, though seemingly counterproductive for oily skin, can actually help balance sebum when used wisely. Jojoba oil mimics the skin's natural sebum, aiding in oil regulation, while argan oil is loaded with vitamin E and essential fatty acids that soothe and heal the skin. Coconut oil offers antimicrobial properties but should be used sparingly, as it may clog pores for some individuals. These oils work best in small amounts or as part of a well-formulated product.
To manage PCOS-related skin concerns, crafting a consistent skincare routine is key. By focusing on gentle cleansing, hydration, and nourishment, you can help calm your skin while incorporating anti-inflammatory ingredients that support healthier skin.
Start your day with a simple yet effective routine:
This morning routine lays the groundwork for protecting your skin throughout the day while addressing inflammation and oil control.
Your evening routine shifts focus to repair and renewal:
Evenings are when your skin naturally works to repair itself, making this the perfect time to incorporate active treatments.
Active ingredients can be game-changers, but they need to be introduced with care to avoid irritation:
"Active ingredients are important, but knowing when to pull back is more important. Harsh cleansing won't wash away your breakouts; it will aggravate them. It will dry out the skin and possibly cause more breakouts, as the skin cannot heal itself."
Since PCOS skin tends to be more sensitive, it’s wise to consult a dermatologist if you experience ongoing irritation or discomfort.
Managing PCOS-related skin concerns requires products that gently cleanse while addressing inflammation. The focus should be on formulations that are effective yet non-irritating, avoiding pore-clogging ingredients that might exacerbate breakouts.
Gentle Daily Cleansers
A good cleanser is the foundation of any skincare routine. The Antioxidant Plant Protein Facial Cleanser ($29.00) is a popular choice, featuring green tea and aloe vera. It boasts a 4.6/5 rating from 30 Amazon reviews. One user, momoftwo, shared in March 2025 that it "makes my face feel clean and soft".
If you're looking for an affordable option, the Eclat Skincare Salicylic Acid Cleanser ($5.99) offers gentle exfoliation. In January 2025, a reviewer named Bo noted, "It takes only the tiniest amount, cleans my face, and I have no 'tingle' from chemicals".
Other effective options include the Good Molecules Hydrating Facial Cleansing Gel ($11.99) and the Well People Juice Cleanse Soothing Aloe Face Cleanser ($18.00), both of which deliver thorough cleansing with anti-inflammatory benefits.
Moisturizing Essentials
Moisturizers are essential for maintaining skin health, especially for PCOS-prone skin. Look for ingredients like ceramides and squalene to support the skin's barrier, and consider natural oils such as jojoba, coconut, or argan oil to calm inflammation. Many top-rated moisturizers also combine hyaluronic acid with soothing agents like niacinamide and chamomile to tackle dryness and reduce irritation.
Once your cleansing and moisturizing routine is set, consider adding serums and active treatments for more targeted care.
Azelaic Acid Powerhouses
Azelaic acid is a standout ingredient for PCOS skin. The DearMYDEW 10% Azelaic Acid Serum has shown promising results, with clinical trials reporting a 45–53% reduction in sebum production and improved acne control.
For a premium option, the SkinCeuticals Phyto A+ Brightening Treatment ($110) offers a lightweight, oil-free formula designed for sensitive, acne-prone skin. Another notable choice is the Shani Darden Skin Care Rescue Serum ($68), which features a 10% azelaic complex. Contributing editor Deanna Pai shared:
"I was using a prescription-strength azelaic acid to control my breakouts, but swapped to this when it ran out... It's done wonders to take the redness out of my acne and reduce swelling, keeping my skin calm and relatively clear. I also like that it seems to be fading my dark spots too - a win-win."
For budget-conscious shoppers, The Ordinary Azelaic Acid Suspension 10% ($12) and Paula's Choice 10% Azelaic Acid Booster ($39) are excellent alternatives. Dr. Green highlights the latter's "lightweight cream-gel formula, which helps exfoliate the skin for a smoother, more radiant complexion".
Multi-Active Formulations
For those tackling hyperpigmentation and uneven texture, the Lion Pose Unspotted 4X Acid Jelly Night Serum ($79) combines azelaic acid with tranexamic, glycolic, and lactic acids. Dr. Hadley King explains, "It's a great combination of azelaic and tranexamic acid for decreasing hyperpigmentation, and also contains glycolic and lactic acids to help lift pigment".
If you prefer a customized approach, the Agency by Curology Future Formula ($40) blends over-the-counter and prescription ingredients in one bottle. Allure tester Devon Abelman shared:
"This made me so at ease with my skin journey... It puts everything my skin needs - over-the-counter and prescription ingredients - in one simple bottle."
To round out your routine, consider adding retinoids and a reliable sunscreen for comprehensive care.
Sun Protection Essentials
Sensitive skin benefits from mineral sunscreens, which are less likely to cause irritation. Dr. Nava Greenfield recommends using an SPF 30+ sunscreen for effective broad-spectrum protection.
The EltaMD UV Clear Face Sunscreen ($44) is a dermatologist favorite, with over 44,000 Amazon reviews and a 4.5-star rating. Dr. Debra Ibrahim notes, "It's easy to apply and absorbs into my skin readily - no greasy residue whatsoever".
For more affordable options, the CeraVe Hydrating Mineral Sunscreen Face Sheer Tint ($14) offers zinc oxide protection along with ceramides and niacinamide. The La Roche-Posay Anthelios Ultra Light Fluid Facial Sunscreen ($33) provides a matte finish, ideal for oily or acne-prone skin. Additionally, the Vanicream Facial Moisturizer ($12) and Aveeno Baby Zinc Oxide Mineral Sunscreen Lotion SPF 50 are gentle choices recognized by trusted organizations like the National Eczema Association and the Skin Cancer Foundation.
Retinoid Considerations
When introducing retinoids, start with a low concentration and gradually build tolerance. Pair retinoid use with daily sunscreen application, as these products can increase skin sensitivity to sunlight.
Taking care of your skin goes beyond just applying the right creams and serums. What you eat, how you manage stress, how well you sleep, and your daily habits all play a big role in reducing inflammation. These internal adjustments can enhance the effects of your skincare routine.
What you eat can either fuel or fight the inflammation that often worsens skin issues linked to PCOS. Choosing the right diet can not only improve your skin but also boost your overall well-being.
The Mediterranean Diet
Amanda Stathos, M.S., R.D., L.D.N., a Clinical Dietitian at Johns Hopkins' Sibley Memorial Hospital, highlights the Mediterranean diet as a powerful tool for reducing inflammation. By cutting out saturated fats, processed meats, and refined sugars, this way of eating can make a real difference.
One study in the North American Journal of Medical Sciences found that individuals with PCOS who followed an anti-inflammatory diet for three months saw improvements in weight management and overall health markers. Losing just 5% to 10% of body weight has also been shown to ease PCOS symptoms and even help restore ovulation.
Anti-Inflammatory All-Stars
Stock up on foods like berries, oily fish, leafy greens, and extra virgin olive oil. These ingredients not only reduce inflammation but also help stabilize blood sugar levels. Pairing protein, fiber, and healthy fats in your meals can further regulate blood sugar, minimizing hormone-related inflammation.
What to Cut Back On
Focus on whole, unprocessed foods and reduce your intake of sugar, processed snacks, and trans fats. Opt for meals rich in vegetables, lean proteins (including plant-based options), and whole grains. Research also suggests that a low glycemic index (GI) diet can aid weight loss, reduce body fat, and shrink waist circumference - key benefits for those managing PCOS.
Living with PCOS can increase stress, anxiety, and even depression. Elevated stress levels trigger cortisol production, which can disrupt hormones and worsen inflammation. Adopting daily stress-relief practices is essential for breaking this cycle.
Simple Ways to Reduce Stress
Incorporate mindfulness techniques like meditation, deep breathing, or yoga into your routine. Regular exercise is also crucial - aim for at least 30 minutes of moderate activity most days. For a bigger impact, try to get at least 120 minutes of vigorous exercise per week. This can help lower inflammation and improve insulin sensitivity.
Prioritize Quality Sleep
Good sleep is a cornerstone of stress management and overall health. Aim for 7–9 hours of restful sleep each night. To improve your sleep quality, limit screen time before bed, get some sunlight in the morning, and moderate your caffeine intake. Keep in mind that PCOS is often linked to sleep disturbances and conditions like obstructive sleep apnea, so addressing these issues is key.
Lean on Your Support System
Whether it’s talking to loved ones, joining a support group, or seeking therapy, having a solid support network can help you manage stress more effectively.
Building on earlier discussions about inflammatory triggers and hormone imbalances, a clear strategy for managing PCOS-related skin issues comes into focus. To effectively address PCOS skincare, it's crucial to tackle both hormone imbalances and inflammation at the same time. As Dr. Jolene Brighten, NMD, explains:
"Skincare can be considered the finishing touch if you think of hormone balance as the foundation for your PCOS care."
In essence, skincare serves as the final layer of a well-rounded PCOS management plan.
The numbers highlight why this comprehensive approach matters. Over half of women with PCOS develop type 2 diabetes before reaching 40. Additionally, research shows that 78% of individuals with high androgen levels experience excessive hair growth, and nearly 50% struggle with hormonal acne. These statistics emphasize the need for a dual strategy that combines lifestyle changes with targeted skincare.
For your skincare routine, focus on the essentials: cleanse gently twice a day, use acne-fighting ingredients like salicylic acid or benzoyl peroxide, and apply a broad-spectrum sunscreen daily. Pair these steps with dietary changes - adding omega-3-rich foods, leafy greens, and nuts to your meals can enhance skin health. Steering clear of refined sugars, high-glycemic foods, and dairy often leads to noticeable improvements in acne.
Equally important are sleep and stress management. Aim for 7–8 hours of quality sleep each night, and incorporate stress-reducing practices such as yoga, meditation, or mindfulness into your daily routine. These habits support both your skin and overall health.
For additional guidance, turn to trusted resources. PCOSHelp offers in-depth, evidence-based guides covering fertility, medication options, symptom management, and lifestyle strategies. Their expert-backed information ensures you stay informed and confident as you navigate your PCOS journey, giving you access to the latest treatment options and self-care practices.
To help manage inflammation and support healthier skin when dealing with PCOS, consider adding anti-inflammatory ingredients to your skincare routine. Products containing salicylic acid can be especially helpful in reducing redness and swelling from acne. Additionally, natural options like green tea extract, aloe vera, and rosemary leaf oil are great for soothing irritation and calming sensitive skin.
You might also want to try skincare products with licorice extract, turmeric, or cinnamon essential oil. These ingredients are well-regarded for their ability to ease inflammation. Incorporate them into your routine through cleansers, serums, or spot treatments to address problem areas while giving your skin the care it needs.
To complement your skincare routine and tackle PCOS-related skin challenges, consider incorporating some lifestyle adjustments:
These small but meaningful changes can help with common PCOS skin concerns like acne, inflammation, and hyperpigmentation, amplifying the benefits of your skincare efforts.
Eating in a way that reduces inflammation can play a big role in managing PCOS-related skin issues. Focus on filling your plate with nutrient-packed options like whole grains (think oatmeal, quinoa, or brown rice), non-starchy vegetables (such as broccoli, spinach, and kale), and healthy fats from foods like avocados, nuts, seeds, and fatty fish. Adding legumes like beans and lentils is another great way to get important nutrients your body needs.
On the flip side, steer clear of processed foods, refined sugars, and saturated fats, as they can aggravate inflammation. Many people with PCOS find the Mediterranean diet helpful. It prioritizes whole, unprocessed foods and healthy fats, which not only promote better skin health but also help tackle other PCOS symptoms.
