5 Effective Treatments to Increase Fertility in Women with PCOS

Here we discuss effective treatments to increase the fertility for women with PCOS

March 2, 2024
4 min

Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder that can significantly impact fertility in women. Characterized by irregular menstrual cycles, elevated levels of androgens, and polycystic ovaries, PCOS poses challenges for those trying to conceive. However, there are several effective treatments available that can increase the chances of successful conception. In this blog post, we'll explore five key treatments that can help enhance fertility in women with PCOS.

Using Metformin for PCOS Fertility

Metformin can be helpful in inducing ovulation for women with PCOS

Metformin is a medication traditionally used to treat type 2 diabetes, but it has proven beneficial for women with PCOS as well. By improving insulin sensitivity, Metformin can help lower insulin levels, which in turn can lead to more regular menstrual cycles and improved ovulation. For women with PCOS struggling with insulin resistance, Metformin can be a crucial step toward achieving a successful pregnancy. A Cochrane review of seven RCTs involving 702 women found that the clinical pregnancy rate for metformin versus placebo was significantly increased.

Trying Clomid (Clomiphene Citrate) for PCOS Fertility

Clomid is one of the most commonly prescribed fertility drugs for women with PCOS. It works by stimulating the ovaries to release eggs, promoting ovulation. Clomid is often the first line of treatment for women with PCOS who are trying to conceive, as it has a relatively high success rate in inducing ovulation and increasing the chances of pregnancy. A meta-analysis of 285 women with anovulatory PCOS and BMI less than 30-32 kg/m2 found no significant overall difference in clinical or viable pregnancy rate or live birth rate for metformin versus clomiphene given for 6 months to non-obese women with anovulatory infertility related to PCOS The meta-analysis, in which there was significant statistical heterogeneity, found overall clinical pregnancy rates were 36.7% (52/142) for metformin and 35.7% (51/143) for clomiphene; live birth rates were 30.3% (43/142) for metformin and 30.8% (44/143) for clomiphene.

Letrozole and Fertility

Letrozole, originally used as a breast cancer treatment, has shown promise in treating infertility in women with PCOS. It works similarly to Clomid by inducing ovulation but may be more effective in some cases. Recent studies have suggested that Letrozole could lead to higher ovulation and pregnancy rates compared to Clomid, making it a valuable option for women with PCOS.


Inositol is a naturally occurring substance that plays a role in insulin signaling. Supplementing with inositol, particularly myo-inositol and D-chiro-inositol, has been shown to improve insulin sensitivity and ovarian function in women with PCOS. This can lead to more regular menstrual cycles and increased ovulation rates, thereby enhancing fertility.

Weight Loss to improve Fertility

For women with PCOS who are overweight or obese, weight loss can be a highly effective treatment for improving fertility. Even a modest weight loss of 5-10% of body weight can lead to more regular menstrual cycles and improved ovulation. Weight loss can be achieved through a combination of diet, exercise, and lifestyle changes, and it can significantly increase the chances of conceiving for women with PCOS.


While PCOS can be a challenging condition for women trying to conceive, there are several effective treatments available that can significantly increase fertility. From medication like Metformin, Clomid, and Letrozole to natural supplements like Inositol and lifestyle changes such as weight loss, women with PCOS have various options to explore. It's essential to work closely with a healthcare provider to determine the most appropriate treatment plan based on individual needs and circumstances. With the right approach, many women with PCOS can achieve their dream of becoming pregnant.

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